atm kinase inhibitor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2685	KU-55933	ATM Kinase Inhibitor	ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.		ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
T7122	AZD-7648		DNA-PK
	AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.		DNA-PK
T6612	NU6027		ATM/ATR , DNA-PK , CDK
	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors.		ATM/ATR , DNA-PK , CDK
TN1673	Garcinone C		ATM/ATR , CDK , STAT , AChR , Antifection
	Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effe...		ATM/ATR , CDK , STAT , AChR , Antifection
T5092	AIM-100	AIM100	ACK
	AIM-100 is a Ack1 inhibitor (IC50: 24 nM).		ACK
T62684	ATM Inhibitor-5
	ATM Inhibitor-5 [formula (1)] is a potent inhibitor of the serine/threonine protein kinase ATM.
T63872	KU-60019		ATM/ATR
	KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).		ATM/ATR
T19671	AZ31	AZ 31,AZ-31	ATM/ATR
	AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK f...		ATM/ATR
T70873	M3541		Apoptosis , ATM/ATR
	M3541 is a selectively potent and orally active ATM inhibitor with potential antitumor activity.M-3541 inhibits ATM kinase activity and ATM-mediated signaling by binding to ATM.M3541 prevents activation of DNA damage che...		Apoptosis , ATM/ATR
T2474	KU60019	KU-60019,KU 60019	ATM/ATR
	Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.		ATM/ATR
T62083	Camonsertib	ATR inhibitor 4,RP-3500	ATM/ATR
	Camonsertib (RP-3500) is a selective, orally active ATR kinase inhibitor (ATRi) with an IC50: 1.00 nM in biochemical assays and exhibits potent antitumour effects. Camonsertib is 30 times more selective for ATR than mTOR...		ATM/ATR
T35942	AZ 5704
	Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 μM). Pot...
T63171	ATM Inhibitor-3
	ATM Inhibitor-3 is a potent and selective inhibitor of ATM (IC50: 0.71 nM). ATM Inhibitor-3 inhibits the PI3K kinase family and exhibits good metabolic stability.
T79306	ATM Inhibitor-9		ATM/ATR
	ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].		ATM/ATR
T63317	ATM Inhibitor-4
	ATM Inhibitor -4 is a selective and potent ATM inhibitor (IC50: 0.32 nM) that strongly inhibits the activity of the PI3K kinase family and exhibits good metabolic stability. ATM Inhibitor -4 completely inhibits mTOR at 1...
T60273	Mirin
	Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC 50 =12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activi...
T68870	SU-11752
	SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in ...